Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension

Amlodipine or lisinopril was not better than chlorthalidone in lowering CHD risk in hypertension.

Although not mentioned by Dr. Psaty in his commentary (1), concerns have been raised over the heart failure results in ALLHAT (2). Asymptomatic left ventricular (LV) systolic dysfunction is common in older patients, particularly men and patients with cardiovascular risk factors (3, 4). ALLHAT participants were high-risk patients, and many may have had asymptomatic LV dysfunction that could have...

Amlodipine or lisinopril was not better than chlorthalidone for reducing CVD risk in hypertensive black or nonblack patients.

In black or nonblack patients with hyperten-sion, is amlodipine or lisinopril better than chlorthalidone for reducing cardiovascular disease (CVD)? Design: Randomized controlled trial (Anti-hypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial [ALLHAT]). Patients: 33 357 black and nonblack patients ≥ 55 years of age (mean age 67 y, 35% black, 53% men overall, 54% women among b...

Pravastatin was not better than usual care in reducing all-cause mortality or CHD events.

and commentary also appear in ACP Journal Club 106 Volume 8 July/August 2003 EBM Therapeutics www.evidence-basedmedicine.com group.bmj.com on December 18, 2017 Published by http://ebm.bmj.com/ Downloaded from

Amlodipine plus perindopril was better than atenolol plus bendroflumethiazide for reducing complications in hypertension.

Cardiovascular outcomes in high-risk hypertensive patients stratified by baseline glomerular filtration rate.

BACKGROUND Chronic kidney disease is common in older patients with hypertension. OBJECTIVE To compare rates of coronary heart disease (CHD) and end-stage renal disease (ESRD) events; to determine whether glomerular filtration rate (GFR) independently predicts risk for CHD; and to report the efficacy of first-step treatment with a calcium-channel blocker (amlodipine) or an angiotensin-converti...